06/03/2026
How far would you go for a Five Guy’s burger? ✈️
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Five Guys
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Five Guys is a fast food joint and American restaurant that specializes in burgers, hot dogs, fries, milkshakes and more. Located at 20811 US Hwy. 281 in San Antonio, they use fresh ground beef, double-cook their fries in 100 percent peanut oil, and hand-prepare fresh ingredients every morning to give their customers the best experience possible. They also serve peanuts while you wait! With over 250,000 ways to customize your burger and 1,000+ milkshake combinations, Five Guys is sure to satisfy any craving. Visit them on Us Highway today!
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Address
20811 US Highway 281, Suite 426
San Antonio, TX
78258
Directions to the restaurant located at US Highway in San Antonio:
Public transport:
From downtown, take the Route 96 bus towards Stone Oak Parkway. Get off at the stop closest to US Highway. Walk south on US Highway until you reach your destination.
Driving/Parking:
From downtown, head north on US-281 N. Take exit 182 for Thousand Oaks Dr/Wurzbach Pkwy. Keep right at the fork and follow signs for Thousand Oaks Dr. Turn right onto Thousand Oaks Dr, then turn left onto Jones Maltsberger Rd. Use the left two lanes to turn left onto US-281 S/NE Interstate 410 Loop Frontage Rd. Use the second from the left lane to turn left onto US-281 S/NE Interstate 410 Loop Frontage Rd. Turn right onto North Loop 1604 E Access Rd/Frontage Rd, then turn right onto Vance Jackson Rd. Turn right into the parking lot of the restaurant.
Opening Hours
| Monday | 11am - 10pm |
| Tuesday | 11am - 10pm |
| Wednesday | 11am - 10pm |
| Thursday | 10am - 11pm |
| Friday | 10am - 11pm |
| Saturday | 10am - 11pm |
| Sunday | 10am - 11pm |
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What people say
Fast food restaurants are a staple in American culture, offering quick and convenient meals for those on-the-go. And when it comes to fast food burgers, Five Guys is a top contender. Located on US Highway in San Antonio, this fast food joint offers classic burgers made with fresh ground beef - no freezers here! But that's not all - their fries are double-cooked in 100 percent peanut oil, giving them a crispy exterior and fluffy interior. And if you're looking for something sweet to wash it all down, Five Guys has over 1,000 milkshake combinations to choose from. With hand-prepared fresh ingredients every morning and peanuts available while you wait, Five Guys strives to provide the best experience possible for their customers. Plus, with more than 250,000 ways to customize your burger, you can create the perfect meal just for you. So next time you're craving a delicious burger and fries combo, head over to Five Guys on US Highway in San Antonio - your taste buds will thank you!