Jersey Mike’s Subs is a fast-casual sub sandwich franchise known for authentic East Coast-style subs made with fresh, sliced ingredients served on freshly baked bread. Originating at the Jersey Shore in 1956, the brand has grown to more than 2,500 locations nationwide and follows the same foundational bread recipe it began with over 60 years ago. With a “Sub Above” approach focused on quality and freshness, Jersey Mike’s also emphasizes community support as part of its mission, making it a staple street-location option along Us Highway 281.
21025 US Highway 281 Unit 45
San Antonio, TX
78258
Jersey Mike’s Subs (Us Highway 281), San Antonio
Driving directions
- From downtown San Antonio: Take I-10 W toward US-281 N. Continue on US-281 N and follow signs for the nearest exit/turnoff along US-281. Turn into the shopping area/parking lot at the store’s address on US-281.
- Parking: Use the on-site parking lot in front of or beside the storefront. Allow extra time during peak lunch hours; spaces can fill quickly near major intersections.
Public transport options
- VIA bus: Use VIA Metropolitan Transit routes that serve US Highway 281 corridors, then walk from the closest stop to the restaurant (typically a short walk depending on the exact stop location).
- Plan stops by address: Search within VIA’s trip planner for “US 281” and select a nearby stop, then use walking directions to reach the storefront in the adjacent shopping area.
| Monday | 10am - 9pm |
| Tuesday | 10am - 9pm |
| Wednesday | 10am - 9pm |
| Thursday | 10am - 9pm |
| Friday | 10am - 9pm |
| Saturday | 10am - 9pm |
| Sunday | 10am - 9pm |
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Jersey Mike's Subs on Us Highway 281 in San Antonio is a standout fast-casual option for anyone craving authentic East Coast-style sub sandwiches. The shop focuses on fresh, quality ingredients and delivers the classic Northeast sub experience with freshly baked bread and subs made with fresh slicing. It’s the kind of place that keeps things consistent, using the same recipe approach that Jersey Mike's has been known for since it began at the Jersey Shore in 1956.
Beyond great food, Jersey Mike's also has a strong reputation for community involvement and support. With its “Sub Above” philosophy, this location offers a reliable go-to for satisfying meals made with care—ideal for lunch or an easy dinner stop along Us Highway 281.
